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:: Volume 14, Number 2 (6-2016) ::
2016, 14(2): 75-79 Back to browse issues page
The Effect of Immobilization Stress on the Induction of Diabetes Mellitus in Rats
manzar banoo Shojaeifard , zahra Vojdani, saeed Karbaly-doust, samira Malekzadeh
phd Department of Physiology, Fasa University of Medical Sciences, Fasa, Iran , shojaeim@sums.ac.ir
Abstract:   (1503 Views)

Purpose: The present study aimed to investigate the effect of immobilization stress on the
induction of diabetes mellitus in rats.
Materials and Methods: In this experimental study 30 mature male rats with an average weight
of 200-220 gr were randomly divided into three groups of ten each. Group I served as the control
while the experiment groups were Group II (10 days) and Groups III (30 days), which were
immobilized in restraining cages twice a day for 45 minutes each time. After the last induction
of stress period, blood samples were taken. Glucose was analyzed via the glucose oxidase
method, and the levels of glucocorticoid and insulin were determined by radio immunoassay.
Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests.
Results: The results showed that stress could affect the induction of diabetes by increasing blood
glucose, insulin, and glucocorticoid; these changes, however, were not statistically significant.
Conclusion: Our data showed that immobilization stress causes the induction of diabetes mellitus
in rats.

Keywords: immobilization stress, diabetes mellitus, insulin, glucocorticoid.
Full-Text [PDF 302 kb]   (770 Downloads)    
Type of Study: Original (Research) | Subject: Healthcare Management
Received: 2016/04/12 | Accepted: 2016/09/3 | Published: 2016/09/3
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Shojaeifard M B, Vojdani Z, Karbaly-doust S, Malekzadeh S. The Effect of Immobilization Stress on the Induction of Diabetes Mellitus in Rats. Ann Mil Health Sci Res. 2016; 14 (2) :75-79
URL: http://journals.ajaums.ac.ir/article-1-1310-en.html
Volume 14, Number 2 (6-2016) Back to browse issues page
سالنامه پژوهش علوم سلامت و نظامی Ann Mil Health Sci Res
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